Nizonide 500 Tablet (Nitazoxanide 500)

Nizonide 500 Tablet is a prescription antiparasitic and antiprotozoal medication containing 500 mg of nitazoxanide, manufactured by Lupin Ltd. It is primarily used to treat diarrhea caused by intestinal parasitic infections, such as those from Giardia lamblia and Cryptosporidium parvum, often referred to as traveler’s diarrhea. Nitazoxanide, a thiazolide, inhibits parasite energy metabolism by disrupting critical chemical processes, effectively killing protozoa and certain helminths. Taken orally with food every 12 hours for 3 days, it is suitable for adults and children aged 12 and older, as the tablet’s high nitazoxanide content exceeds pediatric dosing needs for younger children. Its low systemic absorption minimizes side effects, but it is less effective in immunocompromised patients (e.g., HIV-infected). Medical supervision is required due to potential side effects and interactions, particularly for those with liver, kidney, or immune system issues.

Uses

• Treats diarrhea caused by Giardia lamblia or Cryptosporidium parvum.
• Manages parasitic infections like amebiasis and helminth infections.
• Off-label use for viral gastroenteritis or other protozoal infections (under medical guidance).
• Suitable for adults and children aged 12 and older.

Nizonide 500 Tablet (Nitazoxanide 500) Benefits

• Rapidly relieves diarrhea by killing infection-causing parasites.
• Short 3-day treatment course ensures high compliance.
• Effective against multiple protozoa and some helminths.
• Minimal systemic absorption reduces widespread side effects.
• Improves symptoms like loose stools and abdominal discomfort.
• Prevents recurrence when full course is completed.

Side Effects

• Common: nausea, vomiting, abdominal pain, headache, dizziness.
• Less common: fever, hair loss, urine discoloration (greenish), diarrhea.
• Rare: severe allergic reactions (rash, swelling, breathing difficulties).
• Serious: liver dysfunction (jaundice, fatigue); seek immediate medical help.
• Most side effects resolve; consult a doctor if persistent or severe.

Safety Advice

• Avoid if allergic to nitazoxanide or excipients (e.g., maize starch, soy lecithin).
• Not for children under 12 (use oral suspension for younger patients).
• Consult a doctor if pregnant, breastfeeding, or with liver/kidney issues.
• Take with food to enhance absorption and reduce stomach upset.
• Avoid alcohol, as it may worsen side effects like dizziness.
• Store at 20–25°C in a dry place, away from children; discard unused tablets safely.