RYBELSUS 14 mg is an oral semaglutide tablet prescribed for adults with type 2 diabetes to improve glycemic control and support weight management. It’s taken once daily on an empty stomach, starting at lower doses and titrated up for optimal effect. Common side effects include nausea, diarrhea, and abdominal pain; dosage adjustments help minimize these. Use only under healthcare supervision.
Rybelsus 14 mg Tablet
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SKU: N/A
Categories: Diabetes, OL1, Weight Loss
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Description
Rybelsus 14 mg Tablet, manufactured by Novo Nordisk India Pvt. Ltd., contains Semaglutide (14 mg), an oral glucagon-like peptide-1 (GLP-1) receptor agonist that actively manages type 2 diabetes mellitus in adults. It stimulates insulin release, reduces glucagon secretion, and slows gastric emptying to lower blood sugar levels. Used alongside diet and exercise, Rybelsus enhances glycemic control, reduces A1C, and may promote weight loss, offering a convenient oral alternative to injectable GLP-1 therapies under medical supervision.
Benefits
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Controls Blood Sugar: Rybelsus boosts insulin secretion and reduces liver glucose production, effectively lowering A1C levels by 0.6–1.4 percentage points.
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Promotes Weight Loss: While not FDA-approved for weight loss, it helps patients lose an average of 8.1 pounds (3.7 kg) over 26 weeks, aiding weight management.
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Reduces Cardiovascular Risks: Studies suggest a potential reduction in heart attack and stroke risk, though results are not statistically significant.
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Convenient Oral Dosing: As the first oral GLP-1 agonist, it eliminates the need for injections, improving patient compliance.
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Minimizes Hypoglycemia Risk: When used alone or with metformin/SGLT2 inhibitors, it poses a low risk of low blood sugar compared to insulin or sulfonylureas.
Uses
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Type 2 Diabetes Management: Improves glycemic control in adults with type 2 diabetes as monotherapy when metformin is unsuitable or in combination with other diabetes medications (e.g., metformin, SGLT2 inhibitors, sulfonylureas, insulin).
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Weight Management Support: Off-label use may support weight loss in type 2 diabetes patients when combined with diet and exercise.
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Cardiovascular Risk Reduction: May reduce major cardiovascular events in high-risk patients, though not primarily approved for this purpose.
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Adjunct to Lifestyle Changes: Enhances the effects of a balanced diet and regular exercise to prevent diabetes complications like kidney damage or vision loss.
Side Effects
Rybelsus 14 mg may cause side effects, particularly when starting or increasing the dose. Most are manageable, but consult your doctor if symptoms persist or worsen.
Common Side Effects
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Nausea (more common at 14 mg than 7 mg)
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Abdominal pain
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Diarrhea
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Decreased appetite
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Vomiting
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Constipation
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Hypoglycemia (low blood sugar, especially with insulin or sulfonylureas; symptoms include dizziness, sweating, shakiness)
Serious Side Effects (Rare)
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Pancreatitis (severe abdominal pain radiating to the back, with or without vomiting)
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Diabetic retinopathy complications (vision changes or worsening)
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Severe allergic reactions (e.g., rash, swelling, difficulty breathing)
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Kidney problems (e.g., reduced urine output, swelling)
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Non-arteritic anterior ischemic optic neuropathy (NAION; sudden vision loss, very rare)
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Gallbladder issues (e.g., gallstones, cholecystitis)
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Thyroid tumors (seen in animal studies; human risk unclear)
Note: Stop Rybelsus and seek immediate medical help for severe abdominal pain, vision changes, or allergic reactions. Monitor blood sugar regularly when combined with insulin or sulfonylureas to prevent hypoglycemia. Report side effects to the FDA at 1-800-FDA-1088 or https://www.fda.gov/Safety/MedWatch.
FAQs
Q: How do I take Rybelsus 14 mg?
A: Take one 14 mg tablet once daily on an empty stomach, at least 30 minutes before your first meal, drink, or other oral medications, with no more than 4 ounces (120 mL) of plain water. Swallow whole; do not split, crush, or chew. Typically, start with 3 mg (R1) or 1.5 mg (R2) for 30 days, then increase to 7 mg (R1) or 4 mg (R2), and if needed, to 14 mg (R1) or 9 mg (R2) after another 30 days. Do not take more than one tablet daily.
Q: Can pregnant or breastfeeding women take Rybelsus 14 mg?
A: Avoid Rybelsus during pregnancy, as it may harm the fetus; stop at least 2 months before planning pregnancy. Breastfeeding mothers should consult their doctor, as it’s unknown if Semaglutide passes into breast milk. Discuss contraception and alternatives with your doctor.
Q: Is Rybelsus safe for children?
A: Rybelsus is not approved for children under 18, as safety and efficacy are not established. Consult a pediatrician for alternative diabetes treatments.
Q: Can I consume alcohol while taking Rybelsus 14 mg?
A: Limit alcohol, as it may affect blood sugar levels and increase risks of hypoglycemia or lactic acidosis, especially with other diabetes medications. Consult your doctor for guidance.
Q: Are there dietary restrictions with Rybelsus 14 mg?
A: Take Rybelsus 30 minutes before food, drinks (except water), or other oral medications to ensure absorption. Follow a balanced, low-sugar diet (e.g., whole grains, vegetables, lean proteins) and avoid fatty, spicy, or greasy foods to reduce nausea. Stay hydrated and consider ginger or small, frequent meals to manage side effects.
Additional information
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