Tretinoin 0.025% (A – RET)

What is Tretinoin 0.025% (A-RET)?

Tretinoin 0.025% (A-RET) is a prescription topical gel containing tretinoin, a retinoid derived from vitamin A, manufactured by Menarini India Pvt Ltd. Doctors primarily use this medication to treat acne vulgaris. It promotes rapid skin cell turnover, unclogs pores, and reduces inflammation to improve skin clarity.  Tretinoin stimulates the replacement of old skin cells with new ones, preventing the formation of comedones (blackheads and whiteheads) and improving skin texture. Doctors also prescribe A-RET 0.025% for anti-aging purposes. It helps reduce fine wrinkles, hyperpigmentation, and sun damage when used with a proper skincare and sun-avoidance routine. Patients apply the gel once daily at bedtime. It suits adults and adolescents aged 12 and older but requires dermatologist supervision due to possible skin irritation and photosensitivity. The gel comes in a 20-gm tube and should be stored at 20–25°C, away from moisture and light.

Benefits

• Clears acne by reducing pimples, blackheads, and whiteheads through enhanced cell turnover.

• Prevents new acne breakouts by keeping pores clear of oil and dead skin cells.

• Reduces fine wrinkles and improves skin elasticity by boosting collagen production.

• Fades dark spots, sunspots, and hyperpigmentation for a more even skin tone.

• Improves skin texture, minimizing roughness and large pores for smoother skin.

• Offers long-term skin health benefits with consistent use under medical guidance.

Uses

• Treats acne vulgaris (mild to moderate) in adults and adolescents aged 12 and older.

• Manages photoaging, including fine lines, wrinkles, and sun-induced dark spots.

• Addresses hyperpigmentation, such as melasma or post-inflammatory marks.

• Off-label: May be used for conditions like keratosis pilaris under dermatologist supervision.

Side Effects

• Common:

  • Skin dryness, peeling, redness, or irritation.

  • Stinging, burning sensation, or warmth upon application.

  • Temporary worsening of acne (purging) in the first 3–6 weeks.

• Serious (Rare):

  • Severe allergic reactions (rash, swelling, breathing difficulties).

  • Severe skin irritation, blistering, or swelling not resolving with time.

  • Hyper- or hypopigmentation, especially in darker skin tones.

• Precautions:

  • Contraindicated in pregnancy, breastfeeding, or hypersensitivity to tretinoin or vitamin A derivatives.

  • Avoid use in children under 12 years, as safety is not established.

  • Use cautiously in eczema, rosacea, or sensitive skin; consult a dermatologist.

  • Avoid sun exposure, tanning beds, and weather extremes (wind, cold); use SPF 30+ sunscreen and protective clothing.

  • Do not use with benzoyl peroxide, salicylic acid, or other exfoliants unless directed, to prevent irritation.

  • Inform doctor of medications (e.g., tetracycline) to avoid interactions.

  • Apply to clean, dry skin after waiting 20–30 minutes post-cleansing; use a pea-sized amount.

  • Store at 20–25°C, keep tube tightly closed, and avoid freezing.