Susten 400 SR (Progesterone)

What is Susten 400 SR?

Susten 400 SR Tablet is a prescription medication containing natural micronized progesterone (400 mg), a critical female hormone, in a sustained-release formulation. Manufactured by Sun Pharmaceutical Industries Ltd., it ensures a gradual release of progesterone to maintain stable hormone levels. It is used to treat progesterone deficiency, supporting pregnancy, regulating menstrual cycles, and managing hormonal imbalances. Progesterone prepares the uterus for pregnancy by thickening the endometrial lining and prevents premature uterine contractions.

Benefits

• Steady Hormone Release: Sustained-release formulation provides consistent progesterone levels, enhancing efficacy and allowing once-daily dosing for convenience.

• Supports Pregnancy: Strengthens the uterine lining to promote embryo implantation and reduces miscarriage risk in women with progesterone deficiency.

• Regulates Menstruation: Restores regular menstrual cycles in women with secondary amenorrhea caused by low progesterone levels.

• Manages Menopausal Symptoms: In hormone replacement therapy (HRT) with estrogen, it alleviates symptoms like hot flashes, night sweats, and vaginal dryness while preventing endometrial hyperplasia.

Uses

• Female Infertility: Supports luteal phase in assisted reproductive technologies (e.g., IVF or IUI) to improve embryo implantation and pregnancy success rates.

• Threatened Miscarriage: Sustains early pregnancy in women with a history of recurrent miscarriages due to luteal phase insufficiency.

• Secondary Amenorrhea: Induces menstruation in non-menopausal women with absent periods due to progesterone deficiency.

• Hormone Replacement Therapy: Used with estrogen to prevent endometrial hyperplasia in menopausal women and manage menopausal symptoms.

• Menstrual Disorders: Treats irregular or heavy uterine bleeding caused by hormonal imbalances, such as endometriosis or premenstrual syndrome (PMS).

Side Effects

• Common: Headache, dizziness, drowsiness, nausea, bloating, abdominal discomfort, breast tenderness, hot flashes, vaginal discharge, joint pain, mood changes, or constipation. These are generally mild and subside as the body adjusts.

• Serious (Rare): Blood clots (e.g., deep vein thrombosis, pulmonary embolism), severe allergic reactions (rash, swelling, difficulty breathing), jaundice, abnormal vaginal bleeding, or vision changes (blurred or double vision). Seek immediate medical attention if these occur.

• Other: Hair thinning, fluid retention, vaginal yeast infections, or depression. Consult a doctor if symptoms persist or worsen.

• Precautions: Contraindicated in patients with breast, uterine, or liver cancer, undiagnosed vaginal bleeding, blood clots, or liver disease. Use cautiously in patients with asthma, epilepsy, diabetes, kidney/heart conditions, or a history of depression. Avoid smoking and excessive alcohol, as they increase blood clot risk. Inform your doctor of all medications to avoid interactions (e.g., with antifungals like ketoconazole, antiepileptics, or herbal supplements like St. John’s Wort).